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CBDA and CBGA

CBDA and CBGA are two minor cannabinoids found in the hemp plant that have been talked about quite a bit lately. Not only are scientists finding that they have some of the same benefits as the CBD we have all come to know and love, but they are also seeing better effects in lower doses due to the enhanced bioavailability. Additionally, scientists have discovered that it is effective in the fight against Covid 19.

What are they?

To start with, CBDA is short for cannabidiolic acid. CBGA is short for cannabigerolic acid. These are both cannabinoids found in the raw hemp plant. This means they are present in the plant before it is decarboxylated. Decarboxylation involves heating the cannabinoid acids in a hemp plant until they lose their carboxylic acid. The result in this case is CBD and CBG. While the acidic forms have many of the same effects as their decarboxylated counterparts, they do not bind themselves to the endocannabinoid receptors. Instead, they bind to our serotonin receptors. Serotonin regulates mood, nausea, vomiting, and intestinal motility, among other physiological functionsworking together.

Benefits of CBDA

One of the results from CBDA that researchers at Guelph University in Ontario found is that it does a better job reducing anticipatory nausea as well as motion induced nausea. Anticipatory nausea is common with chemotherapy patients, and many are familiar with the condition of motion sickness. In both cases, ingestion of CBDA shows promise in the prevention of vomiting and the queasy feeling associated with nausea.

CBDA is also showing to be more effective in this form to reduce anxiety then CBD due to its proclivity to bind itself to the serotonin receptors versus attaching to the endocannabinoid system.

There have even been studies done showing promise in the prevention of breast cancer. A report in the Journal of Natural Medicine tells how CBDA can inhibit COX-2 to prevent these aggressive breast cancer cells

Benefits of CBGA

CBGA has been shown to aid in the treatment of cardiovascular disease in patients with diabetes. A study done in 2018 showed that CBGA greatly inhibits the enzyme aldose reductase which is a major contributor to the oxidative stress that leads to problems with the heart.

In a separate study in 2018, researchers found that CBGA not only killed colon cancer cells but enhanced early cancer cell death and stopped the cancer cell cycle. Further research looks to explore how CBGA is a valuable tool in fighting colon cancer and preventing the growth of polyps, which can grow into carcinomas.

Fight against Covid-19 virus

When the two are combined, researchers at Oregon State University have found that these molecules bind themselves to the protein spike of the Covid 19 virus, therefore preventing it from infecting healthy human cells. This works much the same way as the current vaccines do. They also discovered that it is effective against the Covid alpha and beta variants. As stated in their abstract it is “Orally bioavailable and with a long history of safe human use, these cannabinoids, isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2.”

Conclusion

As you can see, there has already been some exciting research done on CBDA and CBGA, but there is much more to learn. Considering the bioavailability of these compounds, the proven history of safe use by humans, and the sustainability of a plant-based product, the limits of what these cannabinoids can do is endless. With all the confusion surrounding medicine these days, many people are also searching for products to help them stay healthy naturally. A safe and effective way to reap these and many more benefits is to use Northern Bay CBDA/CBGA 750 mg Tincture.

Sources:

Bolognini, D., Rock, E., Cluny, N., Cascio, M., Limebeer, C., Duncan, M., Stott, C., Javid, F., Parker, L., & Pertwee, R. (2013). Cannabidiolic acid prevents vomiting inSuncus murinusand nausea-induced behaviour in rats by enhancing 5-HT1Areceptor activation. British Journal of Pharmacology, 168(6), 1456–1470. https://doi.org/10.1111/bph.12043

Cannabinoids – Alcohol and Drug Foundation. (2021). Alcohol and Drug Foundation. Retrieved February 13, 2022, from https://adf.org.au/drug-facts/cannabinoids/
Fernandes, M. F., Chan, J. Z., Hung, C. C. J., Tomczewski, M. V., & Duncan, R. E. (2022).

Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein. bioRxiv. https://doi.org/10.1101/2022.01.11.475901
Takeda, S., Misawa, K., Yamamoto, I., & Watanabe, K. (2008). Cannabidiolic Acid as a Selective Cyclooxygenase-2 Inhibitory Component in Cannabis.

Fitoterapia. 2018 Jun; 127:101-108. doi: 10.1016/j.fitote.2018.02.002. Epub 2018 Feb 7.
Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or cannabigerol Antonella Smeriglio 1, Salvatore V Giofrè 2, Enza M Galati 2, Maria T Monforte 2, Nicola Cicero 3, Valeria D’Angelo 2, Gianpaolo Grassi 4, Clara Circosta 2

J Nat Prod 2022 Jan 28;85(1):176-184. doi: 10.1021/acs.jnatprod.1c00946. Epub 2022 Jan 10.Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants Richard B van Breemen 1, Ruth N Muchiri 1, Timothy A Bates 2, Jules B Weinstein 2, Hans C Leier 2, Scotland Farley 2, Fikadu G Tafesse 2

J Nat Med. 2017 Jan;71(1):286-291. doi: 10.1007/s11418-016-1030-0. Epub 2016 Aug 16.Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressivenessShuso Takeda 1 2, Taichi Himeno 2, Kazuhiro Kakizoe 2, Hiroyuki Okazaki 2, Tomoko Okada 3, Kazuhito Watanabe 4, Hironori Aramaki 5 6

Cannabis Cannabinoid Res. 2018 Jun 1;3(1):120-135. doi: 10.1089/can.2018.0010. eCollection 2018. Identification of Synergistic Interaction Between Cannabis-Derived Compounds for Cytotoxic Activity in Colorectal Cancer Cell Lines and Colon Polyps That Induces Apoptosis-Related Cell Death and Distinct Gene Expression Rameshprabu Nallathambi 1, Moran Mazuz 1, Dvory Namdar 1, Michal Shik 1 2, Diana Namintzer 1 2, Ajjampura C Vinayaka 1, Aurel Ion 1, Adi Faigenboim 1, Ahmad Nasser 3, Ido Laish 4, Fred M Konikoff 4 5, Hinanit Koltai 1