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Explanation of Nano-Encapsulated CBD, Faster Onset, and Improved Bioavailability

When a CBD hemp extract is orally ingested in a regular tincture or edible, only a small fraction of CBD is transported from the gastrointestinal tract into the bloodstream. CBD-rich hemp oil, like other oils, is hydrophobic (or “water-fearing”). This means it prefers to be surrounded by itself or other hydrophobic compounds instead of being surrounded by water. Remember that our bodies are made of mostly water.

Since the CBD in regular edibles does not like to dissolve in water, it is carried it to the liver. Only a small fraction of the CBD that reaches the liver is transported into the blood stream, while most of the CBD is metabolized into hydrophilic (or “water-loving”) compounds that are easier to excrete (in urine or feces). This is called the first-pass effect and results in low bioavailability and a slow onset of effects. The percentage of cannabinoids that are transferred into the blood stream, and the speed at which they are transferred, can vary significantly depending on an individual’s unique physiology and metabolism.

Nano-particles are particles that are less than 100 nanometers in diameter. One nanometer is 0.000000001 meters, or 1×10-9 meters. At this very small size scale, particles demonstrate significantly different behaviors when compared to larger particles.

Through our nano-encapsulation process, individual CBD molecules are encapsulated in a hydrophilic carrier. The extremely small size and hydrophilic (or “water-loving”) nature of the nano-encapsulated CBD particles allows the CBD to swiftly transport through the soft tissues in the mouth, throat, and stomach and into the bloodstream. Our nano-encapsulation process also prevents the CBD particles from binding with taste buds, reducing the bitter flavor often associated with CBD.

Nano-particles demonstrate improved bioavailability and faster diffusion into the blood stream when compared to larger particles for two additional reasons: First, by breaking up large particles into smaller particles, more surface area is created for your body’s uptake of the particles. Second, smaller particles diffuse more efficiently through the soft tissues in the gastrointestinal tract enabling a larger proportion of ingested cannabinoids to quickly transport into the blood stream. These improved characteristics of nanoparticles translate to a significantly faster onset time and improved bioavailability of edibles containing nano-encapsulated CBD.